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KMID : 0380020190340030167
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Korean Journal of Biotechnology and Bioengineering
2019 Volume.34 No. 3 p.167 ~ p.172
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Anti-inflammatory Effect of Rubus coreanus Miquel Extract from Jeju Island in LPS-stimulated RAW 264.7 cells
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Park Tae-Jin
Yang Kyong-Wol
Chang Sung-Chan
Kim Seung-Young
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Abstract
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Rubus coreabus Miquel are found in the southern part of Korea and their fruits are known to have anticancer, antioxidant and anti-inflammatory properties. However, the suppressive effect of Rubus coreanus Miquel stem and leaf extract (RSL) on the expression of lipopolysaccharide (LPS) - induced inflammatory cytokines and mediators has not been yet examined. So, we evaluated the anti-inflammatory effect of Rubus coreabus stem and leaf extract in LPS-stimulated RAW264.7 cell. In this study, RSL inhibited the generation proinflammatory cytokines such as of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS) in a concentration dependent manner without no observable toxicity in RAW 264.7 cells. Our results indicate that RSL could be a new source for the ingredients of cosmetics and pharmaceuticals.
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KEYWORD
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Rubus coeanus, lipopolysaccharide, iNOS, COX-2
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